Ph.D. / Assistant Professor
Expertise: Pathogenic bacteriology and genetics, Immunology, Biochemistry, Molecular and Cellular Biology
Email: yu-kumagai [at] juntendo.ac.jp
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Selected papers:
Kumagai et al. Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils. Innate Immun (2020). LINK
Kumagai et al. Cyclic di-GMP Signaling Regulates Invasion by Ehrlichia chaffeensis of Human Monocytes. J Bacteriol (2010). LINK
Biography
Dr. Yumi Ruth KUMAGAI obtained Ph.D. in Pharmaceutical Science at the graduate school, University of Tokyo with genetic and biochemical studies of Escherichia coli type II topoisomerases. Since then, in her almost 17-years career both in Japan and the U.S., she had been studying the interaction of pathogenic bacteria and hosts: biochemical properties and pathogenic functions of bacterial virulence factors such as proteases, outer membrane transporters, secretion systems, and a a small metabolite molecule produced by various pathogenic bacteria including an obligatory anaerobe, spirochetes, and obligatory intracellular bacteria that proliferate only in mammalian immune cells, neutrophils or macrophages; and bacterial and host cell signal transduction systems. Besides these research activities, she had been involved in epidemiological studies, promotion for hygiene status in Thailand, and graduate and undergraduate educations in English. With these scientific background of bacteriology, cell biology, and immunology, her current research interest and target are understanding and efficient controlling of sepsis pathophysiology by applying host immune cell-derived extracellular vesicles.